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Yonghong Liang Ph.D. Te Marautanga o te Marautanga

Yonghong Liang Ph.D. Te Marautanga o te Marautanga

Ngā whakatutukitanga nui

Rangahau Rangahau

  • Sep. 2006-i konei Te mahi ki te Ph.D (Te Tikanga Taiao)
    kaupapa
    1. He rangahau whaitake o te taunekeneke i waenganui i te dapivirine (TMC120) me te HIV-1 whakawhiti i te transcriptase
    2. Te rangahau hononga mahi-a-mahi mo nga diarylpyrimidines kua whakakapihia
    3. Ko te hoahoa, te rangahau, me te rangahau SAR o nga diarylpyrimidines a-a-te-a-β me te β me nga waituhi-kore-nucleoside o te HIV-1 whakawhitinga whakawhitinga
    4. Ko te hoahoa me te whakawhitinga o nga DABO hei kaipiripiri rua o te HIV-1 whakawhiti me te whakauru

  • 2003-2006 Te Kaiwhakahaere Matua
    kaupapa
    1. Ko te whakawhitinga whakawhitinga whakawhitinga-teitei o te whenua-me te hauora-mo te 2-hydroxybenzophenone, 8-hydroxy-4H-naphthalen-1-one, 5-hydroxy-4, 5-naphthoquinone, 1-hydroxy-9, 10-anthraquione, 7-Hydroxy -1-indenone, 5, 8-dihydroxy-1, 4-naphthoquinone), 4, 9-dihydroxyperylene-3, 10-quinone me te hypocrellin A i akohia e te tikanga tikanga.
    2. Ko te whakawhiti i roto i te taiao-inermolecular whakawhitinga i roto i nga papaa o te 5-hydroxyisoxazole-wai, te waihanga DNA (RNA) me te turanga-N-methylformamide i mahia e nga tikanga DFT.
    2002-2003 Te hononga o te hanganga hanganga ine-nui ki te taonga ahupuru matetiki o te ketone me te aldehyde

Awards

Ko te Hītori Matua o te Hunan, ko te 2008

Publications

1. Liang, YH; Ko Chen, FE ONIOM DFT / PM3 nga tatauranga mo te taunekeneke betweenndapivirine me te HIV-1 whakawhitinga whakawhitinga, he waahanga ako. Drug Discov. Tuhinga o mua. 2007, 1, 57-60.

2. Liang, YH; Ko Chen, FE QSAR rangahau mo te diarylpyrimidines ki te HIV-1 te whakawhitinga o te momo rerenga-rerenga me te ira whakaheke. Eur. J. Med. Chem. 2009, 44, 625-631

3. Liang, YH; Feng, XQ; Zeng, ZS; Chen, FE; Balzarini, J. Pannecouque, C .; De Clercq, E. Design, Synthesis, me SAR o Naphtthyl-Torotiara Diarylpyrimidines rite Non-Nucleoside Kaipatu i te HIV-1 Reverse Transcriptase. ChemMedChem 2009, 4, 1537-1545.

4. Feng, XQ; Liang, YH; Zeng, ZS; Chen, FE; Balzarini, J. Pannecouque, C .; De Clercq, E. Whakatikatika Hanganga o DAPY Analogues ki te Mahi Anti-HIV-1. ChemMedChem 2009, 4, 219.

5. Zeng, ZS; Liang, YH; Feng, XQ; Chen, FE; Balzarini, J. Pannecouque, C .; De Clercq, E. Ko te arotakenga o te pene i nga diarylpyrimidines rite nga kaipatu i te kore-nucleoside HIV-1 whakawhiti transcriptase, ChemMedChem 2010, whakaaetia.

6. Liang, YH; Yi, PG Ko nga rangahau mo te hanganga, ko te kaha me te whakawhitinga o te whakawhitinga whakawhitinga o te kakano. Tikanga Pukupuku Matū, 2007, 438, 173.

7. Liang, YH; Yi, PG; Peng, HL Te rangahau o te hanganga, te kaha me te whakawhitinga o te waikawa o te hypocrellin A. Te Tikanga Pukupuku Pukupuku, 2008, 466, 6-10.

8. Liang, YH; Taka, PG. Cao, CZ He rangahau mo te whakawhitinga whakawhitinga awhina i te 5-hydroxyisoxazole. Te Tuhipoka o te Taiao Molecular: Theochem, 2005, 729, 163-167.

9. Yi, PG. Liang, YH; Cao, CZ Ko te whakawhiti o te konupora ranei te whakawhitinga hydrogen-atom i roto i te whenua me nga ahuareka o te 2-hydroxybenzophenone: Ko te Akoranga Aromatawai. Tikanga Ahupūngao, 2005, 319, 297.

10. Yi, PG. Liang, YH Te rangahau kaupapa mo te whakakotahi me nga painga o te whakawhiti i roto i te whenua me te ahuareka o nga ahuatanga. Tikanga Ahupūngao, 2006, 322, 382.

11. Yi, PG. Liang, YH Tang, ZQ Te rangahau o te whakawhiti whakawhitinga protoncular whakawhitinga i roto i nga waahanga motuhake o te 5-hydroxyisoxazole-wai. Tikanga Pükiko Matū, 2006, 2006, 322, 387.

12. Liang, YH; Zeng, ZS; Feng, XQ; Chen, FE; Balzarini, J. Pannecouque, C .; De Clercq, E. Parallel Synthesis and Evaluation Biological o Diarylpyrimidines ki te Mahi Anti-HIV-1 Mahi. Med. Chem. 2010, 18 (13), 4601.

13. Liang, YH; Zeng, ZS; Feng, XQ; Chen, FE; Balzarini, J. Pannecouque, C .; De Clercq, E. Te hoahoa o nga DABO hei kaiwhakawa ruarua o te HIV-1 whakawhiti me te whakauru. J. Med. Chem.

14. Ko Chen, FE, Liang, YH kua neke ake nei i runga i te maha o te taupatupatu a te mate anti-AIDS, i roto i nga tohu matatini (8), Peng, SQ Ed., 2011, 167.

15. Chen, FE, Liang, YH, Zeng, ZS PCT / CN2009 / 075931.

16. Zeng, ZS, Liang, YH, Zhang, JY, Xiong, JC China Patent, CN201110070027.4

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