Monosialotetrahexosylganglioside Sodium (GM1) roro poaka (37758-47-7)

Kei te noho tenei hua (s) i runga i te kirimana APICMO.

Ko te kaha ki te whakaputa, ki te whakahiato me te waihanga nui nui o te rorohiko poaka o Monosialotetrahexosylganglioside Sodium (GM1) (37758-47-7) me te pūnaha whakahaere kounga i raro i te hangahanga CGMP
ture.

Whakaahuatanga

Monosialotetrahexosylganglioside Sodium (GM1) roro poaka (37758-47-7) Whakaahuatanga

Ko nga whaaweera he mahinga nui o nga kiriuhu rorohiko neuronal me te reticulum endoplasmic. Kei roto hoki he mekameka polysaccharide kua herea ki te cramide na roto i te hononga hononga β-glycosidic.

Ko nga Galactosidases ko nga haurangi e heke ana i te GM1. Ko te GM1, e mohiotia ana ko te monosialotetrahexosylganglioside, ko te "prototype" ganglioside, he mema o te raupapa ganglio o nga gangliosides kei roto i tetahi atu waikawa sialic. Kei te GM1 nga āhuatanga hauora o te mate me te painga ki te hangarau kiriuinga me te hangarau, me te tuku i nga neurotrophins i roto i te roro. I tua atu i tana mahi i roto i te hangarau o te roro, ka mahi a GM1 hei pae honohono mo te cholera toxin me E. coli te wera-labile enterotoxin.

Kei te noho tenei hua (s) i runga i te kirimana APICMO. Mena kei te tiro koe i tenei whārangi hei kaiwhakamahi kore-rēhitatia, ko te utu (s) e whakaatuhia ana ko te Utu Rārangi. Hei tiro i to utu, takiuru ma te whakamahi i to tau nama, ka riro hei kaiwhakamahi rēhitatia mā te whakapā atu ki tetahi o o tatou ratonga Ratonga Kiritaki. Ki te whakatakoto i tetahi tono, whakapā atu ki te Ratonga Kiritaki a APICMO.

Monosialotetrahexosylganglioside Sodium (GM1) roro poaka (37758-47-7) Whakaahuatanga

CAS 37758-47-7
CAS Min% 95%
CAS Max% 100%
Tau MDL MFCD00466936
Ki te KAUPAPA KI QPJBWNIQKHGLAU-IQZHVAEDSA-N
Ingoa Toiina, Rauemi ranei Monosialotetrahexosylganglioside Sodium (Porcine roro), GM1
Hauira Purapura Motuhēhē
Puka Puka paura
Packaging /
Tātai rāpoi C73H131N3O31
Taumaha Taumaha (g / mol) 1546.841
Tuhinga o mua CCCCCCCCCCCCCCCCCC (= O) NC (COC1C (C (C (C (O1) CO)
OC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)
CO) O) O) O) NC (= O) C) OC5 (CC (C (C (O5) C (C (CO) O) O) NC (= O)
C) O) C (= O) O) O) O) O) C (C = CCCCCCCCCCCCCC) O
Tae White ranei i waho-ma
Ko te Whakakuku 207-230ºC
anga matou 98%

Te whakamatautau i nga mea I roto i te Whare Kounga Paerewa
Ckaituku Te paura ma te maama; paku iti, te reka; makuku. Ko tenei hua he wairewa i roto i te wai, he iti rawa te rewa i roto i te methanol, kaore i te kuhu i te waihanga anhydrous.
Tāutunga
Whakaaho i te tauhohenga 1 Tangohia te 0.2ml waihanga whakamatautau i raro i te whakataunga o te ihirangi, me te whakauru i te wai 2ml, me te whakauru i te waikawa waikawa waikawa hydrohydrate (hydroquinone 0.2g, te whakakore i te wai 10ml waipiro, te whakauru 90ml waikawa waikawa, te 0.1mol / L Copper sulfate solution 0.25ml, te tiaki i te pouaka) 2ml, te horoi wai horoi mo nga meneti 15, te wairewa puru me te papura, me te waipiro o te waipiro waipiro 5ml, kaore te waipiro waipiro he puru.
Whakaaho i te tauhohenga 2 Tangohia tenei hua e pā ana ki 20mg, tāpirihia te 1ml waikawa waikawa, te wai wera wai wera katoa, kia toru atu nga pata o te wairewa 1, i roto i te wairere wera i te taiepa o te ngongo ka āta whakapirihia te waipiro sulfuric 1ml, kia rua nga papahanga , kia parauri te tautuhinga piti-wai
Te tote konutai Ko te urupare tautuhi o te tote konutai i roto i tenei hua (ko te putanga 2015 te Chinese Pharmacopoeia 0301).
Ko te chromatography waipiro (LC) I roto i te kauwhata a te kiriata i tuhia i raro i te whakataunga o te ihirangi, me rite te wa pupuri mo te otinga matua o te otinga whakamatautau me te wa pupuri o te pito matua o te otinga whakahaere.
Haupae rererangi purapura Ko te mahere whakauru maramarama o tenei hua kia rite ki te mahere o te hua whakahaere (ko te putanga 2015 o te Chinese Pharmacopoeia 0402).
Tirohia
PH 5.0 ~ 6.5
Te marama me te tae o te otinga Me whakamarama te taekore; ki te mea he kapua, kaore e nui atu i te wai paerewa o te raruraru Nama 1th; Mena ka kore te tae o te tae e hohonu atu i te otinga tae o te Nama Nama 1th.
Te Whakariterite Teitei Ko te otinga kua oti te whakaoti kia marama me te whai kiko i muri i te teitei teitei, kaore he waiu miraka, kaore he rereke
Te hiranga o te whakaaro (Te purongo rereke) ≤50000
Te katoa o te waikawa Sialic E ai ki te whakamahinga hua hua maroke, ko te wai o te waikawa me 19.0 ~ 21.0%
matū e pā ana Ko te waikawa Sialic ≤0.3%; GD3, GD1a, he pokekore te mohiotia ko ≤ 0.5%; kino me te ≤2.0%
pūmua ≤1.0%
He pokekore te taimaha o te taimaha ≤0.5%
Ngā whakarewa taiao Methanol ≤ 0.1%; acetone ≤ 0.3%; Trichloromethane ≤0.003%
Water ≤4.0%
Te wera o te toenga ≤5.0%
He whakarewa taimaha ≤20ppm
He mate kino rawa Ture Whakatau
Ngā matū antihypertensive Kia rite ki nga whakaritenga (maha nga waahanga whakahaere)
Pyrogen Kia rite ki nga whakaritenga (maha nga waahanga whakahaere)
Nga waahanga umanga Ko te tapeke o nga huaketo aukati he <100cfu / g, me te tapeke o nga mowhiti me nga reta me <50cfu / g
Taumahi ≥98.0%

Monosialotetrahexosylganglioside Sodium (GM1) roro poaka (37758-47-7) Te Haumaru me te Whakaaetanga

Kaupapa GHS H

  • H318-H302-H335-H315
  • Ka raruraru i nga kanohi kino.
  • He kino ki te horomia.
  • Ka taea e te mamae o te rewharewha.
  • Ko te mamae o te kiri.

Te Tauraki GHS P

  • P261-P280-P305+P351+P338-P304+P340-P405-P501a
  • Ahanoa i te pupuhi i te puehu / te paraoa / te hau / te kohu / te pupuhi / te pupuhi.
  • Whakanohoia nga totikiri haumaru / kakahu tiaki / tiaki kanohi / kanohi.
  • MĀ TE KAUPAPA: Whakakotahitia te wai ki te wai mo etahi meneti. Tangohia nga arotahi whakapiri, ki te mea kei te noho me te ngawari ki te mahi. Haere tonu ki te horoi.
  • MĀ TE KAUPAPA: Tangohia ki te hau hou me te okioki i te tūranga pai mo te hau.
  • Kei te pupuri i te taonga.
  • Tuhia nga ihirangi / putea kia rite ki nga tikanga o te rohe / rohe / motu / ao.

WHAKATŪPATO: Ko nga korero i whakawhiwhia ki tenei pae tukutuku i whakawhanaketia i raro i nga ritenga o te ture a te Euroopu (EU) me te tika ki to maatau mohio, korero me te whakapono i te ra i tuhia ai. Ko nga korero i homai i hangaia hei awhina mo te whakahaere me te whakamahi haumaru. Kaore e whakaarohia he waahana, he kounga kounga.

Tefito

Ko te Ganglioside GM1-transcytosis whakawhitiwhiti o te tolera o te cholera e whakawhiti ana i te huarahi rerograde me te whakawhirinaki ki te hanganga o te rohe cramura.

Biol. Chem. 288 (36), 25804-9, (2013)

Ko te mate o te cholera e mate ana i te mate diarrheal ma te honohono i te GM1 i runga i te membrane apical o nga pukupuku epithelial intestinal polarized me te rerograde hokohoko mā te tohatoha i nga endosomes, te trans-Golgi ...

Ko te peptide amyloid-β-mate o Alzheimer e pā ana ki te rahi o nga hiko o te raft-mimicking Lo rohe i roto i te Bilayers lipid GM1.

Staneva G, Puff N, Stanimirov S, Tochev T, Angelova MI, Seigneuret M.

Tuhinga Tae. 2018 Dec 5; 14 (47): 9609-9618. doi: 10.1039 / c8sm01636d.PMID: 30457145

Monosialotetrahexosylganglioside Sodium (GM1) roro poaka (37758-47-7) Ratonga Hangarau:

Kei to tatou kapa o nga kaitaiao nga wheako ki nga waahanga katoa o te rangahau, tae atu ki te Life Science, Te Hangarau Rauemi, te Hinengaro Hinairo, te Chromatography, te Tatauranga me etahi atu.

Monosialotetrahexosylganglioside Sodium (GM1) poaka poaka (37758-47-7) Puku Whakatau & Tauira:

Me nui ake nga waahanga mo to whakawhanaketanga, mahi mahi, rangahau ranei?


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