Whakaahuatanga

2-Chloro-4-Amino-6,7-Dimethoxyquinazoline(23680-84-4) video

He Quinazolines he hapu nui o pūhui heterocyclic ki assays properties.Cytotoxicity anti-mate pukupuku i whakamana hoki pūhui katoa ki rerekē rārangi pūtau pērā i mate pukupuku kopirua Human (HCT116), Human kanisā ma'i myeloid (K562) me te mate pukupuku uma Human (SKBR3) raina pūtau te whakamahi i te 3- (4,5-Dimethylthiazol-2-yl) -2,5-Diphenyl tetrazolium Bromide (MTT), te awa a Trypan me te Lactose dehydrogenase tukatuka tuku. I aromatawaihia nga punaha i tīpakohia mo o raatau pukupuku anti-tumo me te angiogenic i runga i te tauira aporo EAC. I tohua te rangahau o te puehu ki te mahinga 2D me te kaha o te kaha ki te whakaheke i te OPLS 2005.

Ko te rangahau o naianei e arotahi ana ki te whakataurite i te kaha me te whiriwhiringa me te pumau i roto i te hanganga taiao i roto i te whakarereketanga hanganga ki te pae whakauru i runga i te tumuaki quinazoline. Ko te hanganga o te mahi hanganga hanganga me nga hanganga-hanganga-hanganga mo tenei kaitautoko ATM kinase tenei quinazoline hei tautuhi i nga rereketanga o te hanganga me te waahanga whakarei ake me te pai o te taiao. E whakaatu ana, he mea nui te rōpū C-7-methoxy mo te kaha, ko te whakakapi i te rōpū C-6-methoxy tino pai ake te whakahou i te hauora me te kore e kaha ki te kaha. Ko nga korero korero 20, 27g, me 27n i tohua i runga i te hangarau i roto i te vitamin in vitro, ka aromatawaihia i roto i nga mahi whakarororo mo te rongoora me te kounga. Ko te 27g i hangaia he tino whakapai ake i nga rongoāpatoetiki e pā ana ki te 4. Ko te 27g ano hoki he nui ake te whiriwhiri i etahi atu kinases atu i te 4. No reira, ko 27g te kaitono pai mo te whakawhanaketanga ano hei rauropi-arotahi.

2-Chloro-4-Amino-6,7-Dimethoxyquinazoline(23680-84-4) Specifications

CAS	23680-84-4
CAS Min%	95.0
CAS Max%	100.0
Tau MDL	MFCD00051734
Ki te KAUPAPA KI	HWIIAAVGRHKSOJ-UHFFFAOYSA-N
Ingoa Toiina, Rauemi ranei	2-Chloro-4-amino-6,7-dimethoxyquinazoline
Hauira Purapura	Motuhēhē
Puka Puka	Powder or Chunks
Packaging	Pounamu tio
Tātai rāpoi	C10H10ClN3O2
Taumaha Taumaha (g / mol)	239.66
Tuhinga o mua	Clc2nc1c (cc (OC) c (OC) c1) c (n2) N
Tae	Pae-ma
Ko te Whakakuku	262-268 ° C
anga matou	95%

2-Chloro-4-Amino-6,7-Dimethoxyquinazoline (23680-84-4) Te Haumaru me te Whakaaetanga

(23680-84-4) Te whakaahuatanga haumaru:

♦ Ko te mamae o te kiri

♦ Ko te ahua kino o te kanohi

♦ Ka meinga e koe te mamae o te hauhanga

(23680-84-4) Te korero whakatupato:

♦ Ahanoa i te pupuhi i te puehu / te paowa / te hau / te kohu / vapors / pupuhi.

♦ Horoi i te kiri i muri i te mahinga.

♦ Whakamahia anake i waho, i roto ranei i tetahi waahi pai.

♦ Te wero i nga karauna tiaki / te tiaki / te tiaki kanohi / kanohi.

♦ Tuhia i roto i tetahi waahi pai. Kia mau tonu te pouaka.

♦ Tuhia nga ihirangi / putea ki tetahi tipu tipu kua whakakorehia.

WHAKATŪPATO: Ko nga korero i whakawhiwhia ki tenei pae tukutuku i whakawhanaketia i raro i nga ritenga o te ture a te Euroopu (EU) me te tika ki to maatau mohio, korero me te whakapono i te ra i tuhia ai. Ko nga korero i homai i hangaia hei awhina mo te whakahaere me te whakamahi haumaru. Kaore e whakaarohia he waahana, he kounga kounga.

2-Chloro-4-Amino-6,7-Dimethoxyquinazoline(23680-84-4) Articles

Ko te tohu me te aromatawai koiora o te tuhinga quinazoline-sulfonamides hei kaihautū anti-kano

I whakawhanakehia tetahi huarahi ohaoha nui ki te N- (quinazoline-4-yl) sulfonamides me te whakahuihui i nga momo aryl, hetero aryl, alkyl me cyclopropyl sulfonamides i nga hua pai.

Bioorganic and Medicinal Chemistry Letters 2017 vol. 27 # 9 p. 1923 - 1928

Ko nga kaitautoko ROS1 kinase mo nga rongoā raukati-e hāngai ana

Ko te ROS1 he purapura rongonui transomaprane protein pūtaiao kinase e whakahaere ana i ētahi tukanga pūtau rite apoptosis, ora, rerekētanga, whakawhānui, nekehanga pūtau, me te huringa.

Te Hiko Hinengaro o Naianei 2016. 23 # 2 p. 142 - 160

2-Chloro-4-Amino-6,7-Dimethoxyquinazoline(23680-84-4) Technical Service:

Kei to tatou kapa o nga kaitaiao nga wheako ki nga waahanga katoa o te rangahau, tae atu ki te Life Science, Te Hangarau Rauemi, te Hinengaro Hinairo, te Chromatography, te Tatauranga me etahi atu.

2-Chloro-4-Amino-6,7-Dimethoxyquinazoline (23680-84-4) Whakahua Puku & Tauira:

Me nui ake nga waahanga mo to whakawhanaketanga, mahi mahi, rangahau ranei?

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