2-Oxa-6-azaspiro[3.4]octane (1408075-00-2)

Kei te noho tenei hua (s) i runga i te kirimana APICMO.

Ko te kaha ki te whakaputa, te whakahiato me te waihanga i te rahi o te 2-Oxa-6-azaspiro [3.4] octane (1408075-00-2) me te pūnaha whakahaere kounga i raro i te hangahanga CGMP
ture.

SKU: 1408075-00-2 Kāwai:

Whakaahuatanga

2-Oxa-6-azaspiro[3.4]octane (1408075-00-2) video

I whakaakonahia te hoahoa me te whakawhitinga o te tuhinga azaspirocycle me te azetidine hei whakakapi i nga wahanga 4-anilinoquinazoline. Ko nga mahi aukati EGFR me te kaha o te whakapae antitumor i roto i enei pukupuku hou ki te rua o nga raina pukupuku mate pukupuku a HCC827 me A549 kua arotakengia. Tirohia mehemea ko te nuinga o nga kaiwhakahaere o te whaainga kei te kaha ki te whakakore. I tua atu, kua kitea te 21g pūhui me te 2-oxa-6-azaspiro [3.4] octane whakakapi ki te whai i nga mahi aukati EGFR teitei, me te kaha whakapae antitumor rite ki te gefitinib me te whakapai ake i te wai.

I tua atu, ko te piperazine me te morpholine he mahinga noa i nga raau taero. Ka taea e te hoahoa me te whakawhitinga o o raanei te awhina ki te torotoro i te matū ki te matū rongoa. Na roto i [3 + 2] cycloaddition, ko te whakahiato pai ake o te 6-benzyl-2,6-diazaspiro [3.4] octane oxalate me te 2-oxa-6-azaspiro [3.4] octane hei whakakapi mo te piperazine me te morpholine. Ka taea te tiki i nga waahi maha-maha o nga waehui i nga hua o te tiketike.

Kei te noho tenei hua (s) i runga i te kirimana APICMO. Mena kei te tiro koe i tenei whārangi hei kaiwhakamahi kore-rēhitatia, ko te utu (s) e whakaatuhia ana ko te Utu Rārangi. Hei tiro i to utu, takiuru ma te whakamahi i to tau nama, ka riro hei kaiwhakamahi rēhitatia mā te whakapā atu ki tetahi o o tatou ratonga Ratonga Kiritaki. Ki te whakatakoto i tetahi tono, whakapā atu ki te Ratonga Kiritaki a APICMO.

2-Oxa-6-azaspiro[3.4]octane (1408075-00-2) Specifications

CAS 1408075-00-2
CAS Min% 95.0
CAS Max% 97.0
Tau MDL MFCD22123302
Ki te KAUPAPA KI ZHAIMJRKJKQNQI-UHFFFAOYSA-N
Ingoa Toiina, Rauemi ranei 2-Oxa-6-azaspiro [3.4] octane
Hauira Purapura N / He
Puka Puka N / He
Packaging Whakairinga paerewa
Tātai rāpoi C6H11NO
Taumaha Taumaha (g / mol) 113.16 g / mol
Tuhinga o mua C1CNCC12COC2
Tae ma
Ko te Whakakuku N / He
anga matou ≥97%

2-Oxa-6-azaspiro [3.4] octane (1408075-00-2) Te Haumaru me te Whakaaetanga

2-Oxa-6-azaspiro [3.4] octane Whakaahuatanga haumaru:

w Ko te mamae o te kiri [Te whakatupato i te pirau kiri / te riri]

w He raruraru nui o te kanohi [Whakatupato He kino kino kino / kanohi kino]

w Ka meinga te mamae o te rewharewha [Whakatupato I te whaainga o te aukati whaitake, te whakaatu kotahi; Nga wahanga mo te hauhawera)

(1408075-00-2) Kupu Whakatakotoranga:

w Aukati i te pupuhi i te puehu / te paraoa / te hau / te kohu / te pupuhi / te pupuhi.

w Waka ... i muri i te mahinga.

w Whakamahia anake i waho, i roto ranei i tetahi waahi pai.

w Wear potae tiaki / kakahu tiaki / tiaki kanohi / kanohi.

W WHERE I TE WHAKANUI: Horoi me te nui o te wai.

MI TE WHAKAMAHI: Tangohia te tangata ki te hau hou me te noho pai mo te hau.

MĀ TE WHAKAMĀRANGI: Whakanohoia te āta whakaaro ki te wai mō ētahi meneti. Tangohia nga arotahi whakapiri ki te mea me te ngawari ki te mahi - haere tonu te horoi.

w Me karanga he POENTON CENTER ranei he taakuta ... ... ki te mea kaore koe e mate.

w Te maimoatanga motuhake (tirohia ... i runga i tenei tapanga).

W IF SKIN te riri: Te tiki tohutohu hauora / aro.

w Ki te mau tonu te riri o te kanohi: Haere ki te tohutohu hauora / aro.

w Tangohia nga kakahu poke.

w Whakamahia i roto i tetahi waahi pai. Kia mau tonu te pouaka.

w Store kua kati.

w Whakaaturanga ihirangi / ipu ki ...

WHAKATŪPATO: Ko nga korero i whakawhiwhia ki tenei pae tukutuku i whakawhanaketia i raro i nga ritenga o te ture a te Euroopu (EU) me te tika ki to maatau mohio, korero me te whakapono i te ra i tuhia ai. Ko nga korero i homai i hangaia hei awhina mo te whakahaere me te whakamahi haumaru. Kaore e whakaarohia he waahana, he kounga kounga.

Tefito

Ko te tohu o te azaspiro [3.4] octanes ma [3 + 2] cycloadditionWang

Na roto i te [3 + 2] cycloaddition, ko te whakahoutanga pai ake o te 6-benzyl-2,6-diazaspiro [3.4] octane oxalate me 2-oxa-6-azaspiro [3.4] octane hei whakakapi mo te piperazine me te morpholine ...

Hainamana Hainamana o te Ahupūngao Taiao 2015.

Nga heterocycles e wha-maama-kei roto i te 4-anilino-quinazoline nga ngarara rite nga kaiwhakawa kukuwhakahoho (EGFR) kinukore

I tua atu, kua kitea te 21g pūhui me te 2-oxa-6-azaspiro [3.4] octane whakakapi ki te whai i nga mahi aukati EGFR teitei, me te kaha whakapae antitumor e rite ana ki te gefitinib me te whakapai ake i te wai ...

Bioorganic and Medicinal Chemistry Letters 2013.

2-Oxa-6-azaspiro [3.4] octane (1408075-00-2) Ratonga Hangarau:

Kei to tatou kapa o nga kaitaiao nga wheako ki nga waahanga katoa o te rangahau, tae atu ki te Life Science, Te Hangarau Rauemi, te Hinengaro Hinairo, te Chromatography, te Tatauranga me etahi atu.

2-Oxa-6-azaspiro [3.4] octane (1408075-00-2) Whakahua Puku & Tauira:

Me nui ake nga waahanga mo to whakawhanaketanga, mahi mahi, rangahau ranei?


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