4-Hydroxyquinoline-3-carboxylic acid (13721-01-2)

Kei te noho tenei hua (s) i runga i te kirimana APICMO.

Ko te kaha ki te whakaputa, ki te whakahiato me te waihanga i te rahi o te 4-Hydroxyquinoline-3-carboxylic acid (13721-01-2) me te pūnaha whakahaere kounga i raro i te hangahanga CGMP
ture.

SKU: 13721-01-2 Kāwai:

Whakaahuatanga

4-Hydroxyquinoline-3-carboxylic acid (13721-01-2) ataata

4-Hydroxyquinoline-3-carboxylic acid (13721-01-2) Whakatakotoranga

CAS 13721-01-2
CAS Min% 98%
CAS Max% 100%
Tau MDL MFCD00498984
Ki te KAUPAPA KI ILNJBIQQAIIMEY-UHFFFAOYSA-N
Ingoa Toiina, Rauemi ranei 4-Hydroxyquinoline-3-carboxylic waikawa
Hauira Purapura Motuhēhē
Puka Puka Ko te Kino-Maama i 20 ° C
Packaging Pounamu tio
Tātai rāpoi C10H7NO3
Taumaha Taumaha (g / mol) 189.17
Tuhinga o mua C1 = CC = C2C (= C1) C (= O) C (= CN2) C (= O) O
Tae White-Yellow
Ko te Whakakuku 267-273 ° C
anga matou ≥98.0%

I te Apicmo.com, ka whakawhanakehia, ka whakahiato, ka hangaia he nui nui o te 4-Dihydro-4-Oxo-Quinoline-3-Carboxylic Acid ma te whakamahi i nga aratohu o te CGMP i raro i to taatau whakahaere kounga tiketike. Na, mehemea e rapu ana koe mo nga rahinga iti, nui ranei o tenei pühui mo te rangahau, whanaketanga ranei, tatauhia ki a Apicmo.com. Whakauru noa atu ki to taatau hoahoa hoahoa me nga kaituku ngaio i tenei ra mo etahi atu korero. Kei raro nei nga korero taipitopito mo te hua.

Nga Synonyms o te 4-Hydroxyquinoline-3-carboxylic acid (13721-01-2)

Ko te 4-oxo-1,4-dihydroquinoline-3-carboxylic acid ko te 4-Quinolone-3-carboxylic acid ranei 4-oxo-1,4-dihydro-3-quinolinecarboxylic acid ranei 4-Oxo-1,4-dihydroquinoline Carboxylic Acid ranei 4- OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID ranei 1,4-Dihydro-4-oxo-3-quinolinecarboxylic acid 1,2-Dihydro-4-oxo-quinoline-3-carboxylic acid ranei 1,4-DIHYDRO-4-OXO-QUINOLINE-3 -CIDBOXYLIC ACID ranei 3-Quinolinecarboxylic waikawa 1,4-dihydro-4-oxo- ranei.

Ngā āhuatanga matū me te matū o te 4-Hydroxyquinoline-3-carboxylic acid (13721-01-2)

Ingoa Huawhenua: 3-Ethoxycarbonyl-4 (1H) -quinolone

Puka Motuhake: C₁₂H₁₁NO₃

Te ahua: Beige Solid

Ko te Whakakuku: 277-279 ° C

Mol. Taumaha: 217.22

Storage: Room Temp

Te whakaheke: DMSO (Hera)

Tautuhinga: Karekau he Raraunga e wātea ana

Kāwai: Aromatics, Pharmaceuticals, Intermediates and Chemicals.

Nga tono a 4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

He nui nga rangahau kua mahia i runga i te Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate hei tuhinga mo te inhibitor endonuclease hauora. Ka mahi ano hoki ratou i nga mokopuna i roto i te pae o te benzodiazepine o te rorohiko o te GABAA.

Te hanganga matū o te 4-oxo-1,4-dihydro-3-quinolinecarboxylic acid;

4-Hydroxyquinoline-3-carboxylic acid (13721-01-2)

4-Hydroxyquinoline-3-carboxylic acid (13721-01-2)

Nga rongoora i nga 4-Oxo-1,4-dihydroquinoline-3-carboxamides

CB 2 ko nga kaiwhiwhi kaiwhiwhi kaiwhiwhi ko etahi o nga rongoa tino rongonui mai i te mea he mahi nui ta ratou i nga tukanga physiopathological o tenei kaiutuutu. Na reira, ko te whanaketanga o te 4-oxo-1,4-dihydroquinoline-3-carboxamides i mahia ki te kaupapa o te whakaatu i nga hononga-hangarau me te hononga-hononga o enei hua. I whakawakia te mana o te kaitaha taha ki te whakaputa i nga potae e mau ana i nga keto me nga motika carboxamido. Ko te mahi o te whaawhita o te quinoline pokapū, i tetahi atu ringa, i whakaakona e te whakaputa 6-, 7-, 8-chloro-4-oxo-1,4-dihydroquinolines, 4-oxo-1,4-dihydrocinnoline, me 4-oxo- 1,4-dihydronaphthyridine tawhito. Ko te painga o enei whakarereketanga i runga i te mahi me te whanaungatanga i te CB2 i tuhia te kaiwhiwhi me te whakaaetia mo te whakamahinga o te tiwhiringa hou CB2 nga kaitautoko kaiwhiwhi.

Ngā āhuatanga kaute o te 4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

Ingoa Tae Uara Taonga
Utu Kotahi Utu Kotahi 1
Tautuhia te Tohu Toro o Atom 0
Atomope Atom Te tatau 0
Te Tautuhi Tae Akerangi Atomorekore 0
Te Tae Tae Tae Taehia Kore 0
Tae Tae Tae Tautuhia 0
Maatau Atom Count 14
Tae Whaimana 0
Ka taea te Whakaritea te Hanga pono
Ko te Monoisotopic Mass 189.043 g / mol
XLogP3-AA 1.8
Motuhake Mae 189.043 g / mol
Te Porow Area Polar Area 66.4 A ^ 2
CACTVS Te Hanga Tohu Paerewa Matua AAADCYBYMAAAAAAAAAAAAAAAAAAAAAA
AAAAWQAAAAAAAAACBAAAAHGAQCAAAD
AzBmAQwyILAAgCIAqTWSACCAAAlAgAIiIE
IZMgIJD7IlZGEYYhksABI2ceY2aOeAAAAAA
ACAAAAAAAAAAQAAAAAAAAAAA ==
Taumaha rāpoi 189.17 g / mol
Tuhinga 309
Ko te Kaute Kaihauturu o te wairangi 2
Tae Tae Rotatable 1
Te Tae Whakaaetanga Hukawai 4

4-Hydroxyquinoline-3-carboxylic acid (13721-01-2) Synthesis

Hei whakakotahi i te raupapa o te 1-cyclopropyl-7- [4 dimethoxy-pyrimidin-2,6-yl-diazenyl) -piperzin-2-yl] -1-fluoro-6-oxo-4-dihydro-quinoline-1,4- te waikawa carboxylic me te 3-cyclopropyl-1- [7- (4-dimethyl-pyrimidin-2,6-yl-diazenyl) -piperzin-2-yl] -1-fluoro-6-oxo-4-dihydro-quinoline-1,4-carboxylic te waikawa me o raatau taiohi me te aromatawai mo o raatau mahi antibacterial.

tikanga

He raupapa o 1-cyclopropyl-7- [4- (2,6 dimethoxy-pyrimidin-2-yl-diazenyl) -piperzin-1-yl] -6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid me te 1-cyclopropyl-7- [4- (2,6-dimethyl-pyrimidin-2-yl-diazenyl) -piperzin-1-yl] -6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid me te i whakahiatohia o raatau taiohi i roto i te whakaheke me te whakaatu i te IR, 1H NMR me te rangahau kaupapa. I aromatawaihia nga punaha matū mo o ratou mahi antibacterial in-vitro ki etahi huaketo Gram-kino me te Gram-positive i te whakamahi i te tikanga tukr-dilution.

Ko te Rohe Hinanga mo te 4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

26892-90-0
4-HYDROXYQUINOLI ...
6-Chloro-5-azaindole
~ 90%

34785-11-0

4-HYDROXYQUINOLI ...

13721-01-2
4-Oxo-1,4-dihydr

4-Hydroxyquinoline-3-carboxylic acid Safety Information

1. Te Tautuhinga Tae

Ingoa: 4-Dihydro-4-oxo-3-quinolinecarboxylic acid

2. Tuhinga o mua

Kai o te Mate: 4-Oxo-1, 4-dihydroquinoline-3-carboxylic acid

Nga korero morearea (s)

  • Ka taea e te mate o te kiri te mate
  • Ka nui te riri o te kanohi

Te korero mo te whakatupato (s)

  • Whakanohia nga Mea Tiaki hei karapu
  • Ki te titiro kanohi: Horoi marie ki te wai ma ki te whakakore i nga matū matū.

3. Raraunga Ture

Piri ki nga Federal, State, me te ture rohe

4. Te waihanga, te korero, te Kai ranei

Ingoa: 1, 4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID

5. Whakarato Maatau

Ingoa Shipping: Whakamahia he korerearea mo te tuku

6. Nga Whakaaro Whakataunga

Kia mau ki etahi atu ture e kiia ana e te paremata: Whakakotahutia nga konupuku ki te hinu whakawera me te whakamahi i te whakauru matū i whakatinanahia e nga kaitahura e rua, ka horoia. Whakamahia nga ture o te kawanatanga, o nga kawanatanga me te mana o te rohe.

7. Toxicological Details

Ngā hua aukati: Te kino e pā ana ki te papa rewharewha me te ingestion.

8. Nga Mahi Awhina Tuatahi

Whakaaetanga kanohi: Me whakarite nga mea kaore e uru atu ki nga mea arotahi. Mehemea ka tupu, ka horoi i ou kanohi ki te wai ma. Kia mau tonu nga kanohi me te rapu i nga mahi hauora tonu.

Whakapā kiri: Ki te mea ka uru atu enei mea kino ki te kiri, horoia me te maha o nga wai ma te whakamahi i te hopi kapi. Kapihia te rohe me te kaimoeka me te korero ki a koe mo o raatau.

Inhalation: Tangohia te tangata e pa ana ki waho o te rohe me te whakahaere i te oxygen i roto i te take e raru ana ia i te raruraru. Whakawhiti atu ki to taakuta mo te rongoa.

Ingoa: A karo i te whakaheke i te ruaki ki te kaipupuri engari ka tuku atu i tana wai ki te inu me te rapu i te awhina hauora.

9. Te Taumahi me te Reactivity

Incompatibilities

He kaha nga kaiwhakahaere pitihana

He waikawa kaha me nga turanga

Nga Waerenga Taerenga

Te karo: Te monoroke karo

Koropiro konupora

Nitrogen: Oxides o te hauota

10. Te whakahaere me te rokiroki

  • Kia tupato me te whakahaere i te hua
  • Ahanoa i te whakawhitinga nui ki nga kai haumaru
  • Whakaritea te taumata o te whakaaturanga matū
  • Kaua e raukahu i roto i te pupuhi me te puehu
  • Whakamahia nga waahanga haumaru kia whai whakaarohia i muri i te whakamaanga
  • A ape i nga kai mai i te tomo ki nga kanohi, kiri me nga kakahu.
  • Kati te ipu
  • Whakamahia anake i roto i te hopi matomato.
  • Tiakina te hua ki te wahi maroke me te hauora
  • Me whakarite he hauora tika i te wa e whakamahia ana.

11. Ngā Mana Whakahaere me te Tiaki Whaiaro

  • Whakanohoia nga makawe haumaru tiaki i runga i nga kanohi.
  • Whakamahia nga ringaringa tiaki i runga i nga ringa ka mau i nga matū
  • Whakanohoia nga kakahu me nga Potae e whakatairanga ana i te matū
  • Whakamahia te matū i roto i te waahanga pai

12. Ngā Āhuatanga Tinana me te Taiao

Te ahua: He kaha

13. Te Taumahi me te Reactivity

Incompatibilities: He kaha nga kaiwhakahaere pitihana pitihana

He waikawa kaha me nga turanga

Nga Waerenga Taerenga

Te karo: Te monoroke karo

Koropiro konupora

Nitrogen: Oxides o te hauota

Ratonga Hangarau

Kei o tatou tohungatanga te wheako i nga waahi rangahau, penei i te Life Science, Te Rauemi Rauemi, te Hinengaro Hinengaro, te Chromatography, te Taatauranga, me te maha atu.

1, 2-Dihydro-4-oxo-quinoline-3-carboxylic acid (13721-01-2) Te Whakatairanga me te Whakarunga Puku:

Me te nui o nga waahanga nui, iti ranei mo to waihanga, whanaketanga, rangahau ranei? Me whakapiki noa i to taatau kaihoko kiritaki i tenei ra hei whakatakoto tikanga.

Bibliography

  1. Baughman, B. et al .: ACS. Chem. Biol., 7, 526 (2012); Gaurav, A. et al .: Mataora. Chem. Res., 20, 192 (2011);
  2. Seongil Kang, Subin Park, Kyung-su Kim, Changsik Song, me Yunmi Lee: Ko te Journal of Organic Chemistry 2018 83 (5), 2694-2705
  3. Banerji, Biswadip; Rangahau Whakawhitiwhiti (Cambridge, United Kingdom) 2005, (43), P5438-5440

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